Engineering 3D Pre-Vascularized Hepatic Tissue
نویسندگان
چکیده
منابع مشابه
Engineering Vascularized Human Adipose Tissue
Introduction Due to complications of currently available therapies, the clinical impetus to engineer adipose tissue for the correction of soft tissue defects is high. Unfortunately, poor survival of in vitro-engineered adipose tissue after transplantation is still a major hurdle for clinical use. The main reason for this poor survival is postulated to be insufficient vascularization. In this st...
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Survival of functional tissue constructs of clinically relevant size depends on the formation of an organized and uniformly distributed network of blood vessels and capillaries. The lack of such vasculature leads to spatio-temporal gradients in oxygen, nutrients and accumulation of waste products inside engineered tissue constructs resulting in negative biological events at the core of the scaf...
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In vitro scaling up of bioengineered tissues is known to be limited by diffusion issues, specifically a lack of vasculature. Here, we report a new strategy for preserving cell viability in three-dimensional tissues using cell sheet technology and a perfusion bioreactor having collagen-based microchannels. When triple-layer cardiac cell sheets are incubated within this bioreactor, endothelial ce...
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PURPOSE: Creating patient-specific replacement organs promises to address shortcomings in transplantation, including the need for immunosuppression and limited donor supply. A major roadblock to tissue engineering is the inability to synthesize an intact circulatory system de novo. Thus, tissues produced by the current paradigm of seeding cellular scaffolds are rendered critically ischemic by t...
متن کاملHepatic Tissue Engineering
Liver disease afflicts over 600 million people worldwide, 30 million of whom are Americans. Liver disease leads to the death of over 40,000 individuals in the United States every year. Liver failure can be generally separated into two major categories: fulminant hepatic failure, also referred to as acute liver failure, and chronic hepatic failure resulting from chronic end-stage liver disorders...
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ژورنال
عنوان ژورنال: Frontiers in Bioengineering and Biotechnology
سال: 2016
ISSN: 2296-4185
DOI: 10.3389/conf.fbioe.2016.01.00056